A Lewis Acid Catalyzed Annulation to 2,1-Benzisoxazoles
نویسندگان
چکیده
منابع مشابه
A Lewis Acid Catalyzed Annulation to 2,1-Benzisoxazoles
We report here a new, atom economical annulation to 2,1-benzisoxazole scaffolds via the BF3·Et2O-catalyzed reaction of glyoxylate esters and nitrosoarenes. The developed method represents a convergent route to this compound class from previously unexplored inputs and provides a range of 2,1-benzisoxazoles in moderate to high yields under convenient conditions. Along with exploration of substrat...
متن کاملLewis acid catalyzed [3 + 2] annulation of ketenimines with donor-acceptor cyclopropanes: an approach to 2-alkylidenepyrrolidine derivatives.
The [3 + 2] annulation reaction of C,C,N-trisubstituted ketenimines with donor-acceptor cyclopropanes bearing aryl, styryl and vinyl substituents at the C2 position, triggered by the Lewis acid Sc(OTf)3, supplies highly substituted pyrrolidines. Activated cyclopropanes fused to naphthalene and [1]benzopyrane nuclei are also suitable substrates in similar transformations, yielding partially satu...
متن کاملDevelopment of fluorous Lewis acid-catalyzed reactions.
Organic synthetic methodology in the 21st century aims to conform to the principles of green sustainable chemistry (GSC) and we may expect that in the future, the realization of GSC will be an important objective for chemical industries. An important aim of synthetic organic chemistry is to implement waste-free and environmentally-benign industrial processes using Lewis acids as versatile as al...
متن کاملA platinum-catalyzed annulation reaction leading to medium-sized rings.
A platinum-catalyzed domino process with intermediate benzopyrylium cations reaches its optimum utility in the formation of 7- and 8-membered rings. With iron(III) chloride, a tetracyclic product is isolated, derived from an oxidative transformation of a metal-carbene intermediate.
متن کاملAntibody-Catalyzed Enantioselective Robinson Annulation
We report an antibody that is remarkable in that it catalyzes both steps of an important synthetic transformation, the Robinson annulation. The Robinson annulation which accomplishes, in net terms, the conversion of a f c occupies a key role in organic synthesis.1 In most instances, the overall annulation is comprised of an alkylation (or Michael addition) step leading to b followed by a cyclod...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2014
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo5015432